| SHORT COMMUNICATION |
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| Year : 2012 | Volume
: 4
| Issue : 2 | Page : 123-126 |
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In vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
Priyanka Yadav1, Aditya Ganeshpurkar1, Gopal Rai2
1 Department of Pharmacology, Shri Ram Institute of Technology -Pharmacy, Jabalpur, Madhya Pradesh, India
2 Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India
Correspondence Address:
Gopal Rai
Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8490.94738
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Objective: This study was undertaken to study in vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Materials and Methods: Total phenolic and flavonoid contents from extract was quantified and H + -K + ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract.
Results: Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. Conclusions: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump. |
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