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Year : 2011  |  Volume : 3  |  Issue : 3  |  Page : 189-193

Cucurbitacins-type triterpene with potent activity on mouse embryonic fibroblast from Cucumis prophetarum, cucurbitaceae

1 Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saud Arabia
2 Department of Health Information Technology, Jeddah Community College, King AbdulAziz University, P.O. Box 80283, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
3 Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA

Correspondence Address:
Seif-Eldin N Ayyad
Department of Chemistry, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Kingdom of Saud Arabia

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Source of Support: SABIC, the Saudi Arabian Company for Basic Industries, for the fi nancial support of this work (MS/8/68), through the collaboration with the Deanship of Scientifi c Research (DSR) at King Abdul-Aziz University, Conflict of Interest: None

DOI: 10.4103/0974-8490.85006

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Background: Higher plants are considered as a well-known source of the potent anticancer metabolites with diversity of chemical structures. For instance, taxol is an amazing diterpene alkaloid had been lunched since 1990. Objective: To isolate the major compounds from the fruit extract of Cucumis prophetarum, Cucurbitaceae, which are mainly responsible for the bioactivities as anticancer. Materials and Methods: Plant material was shady air dried, extracted with equal volume of chloroform/methanol, and fractionated with different adsorbents. The structures of obtained pure compounds were elucidated with different spectroscopic techniques employing 1D ( 1 H and 13 C) and 2D (COSY, HMQC and HMBC) NMR (Nuclear Magnetic Resonance Spectrometry) and ESI-MS (Eelectrospray Ionization Mass Spectrometry) spectroscopy. The pure isolates were tested towards human cancer cell lines, mouse embryonic fibroblast (NIH3T3) and virally transformed form (KA3IT). Results: Two cucurbitacins derivatives, dihydocucurbitacin B (1) and cucurbitacin B (2), had been obtained. Compounds 1 and 2 showed potent inhibitory activities toward NIH3T3 and KA31T with IC 50 0.2, 0.15, 2.5 and 2.0 μg/ml, respectively. Conclusion: The naturally cucurbitacin derivatives (dihydocucurbitacin B and cucurbitacin B) showed potent activities towards NIH3T3 and KA31T, could be considered as a lead of discovering a new anticancer natural drug.

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