| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 2
| Issue : 1 | Page : 36-40 |
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Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb
CO Okoli, AC Ezike, OC Agwagah, PA Akah
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka - 410 001, Enugu State, Nigeria
Correspondence Address:
C O Okoli
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka - 410 001, Enugu State
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8490.60580
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Anticonvulsant and anxiolytic activities of leaf extracts and fraction of Ocimum gratissimum L. (Lamiaceae) were studied using seizures induced by pentylenetetrazol and open-field tests in mice. The results showed that the extracts and fraction increased the latency of tonic and tonic-clonic seizures and death and elicited 50% protection against mortality. In the open-field test, the extracts and fraction decreased the frequency of line crossing, center square entries, rearing against a wall and grooming, whereas grooming duration and freezing frequency and duration were increased. Acute toxicity test in mice gave an oral LD 50 greater than 5000 mg/kg for the methanol extract. These findings suggest that extracts of this plant possess anticonvulsant and anxiolytic-like properties. |
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