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Year : 2010  |  Volume : 2  |  Issue : 1  |  Page : 10-14

Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

1 Faculty of Medicine, Microbiology Unit, AIMST University, Kedah, Malaysia
2 Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi, India
3 Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli, India
4 Faculty of Medicine, 3Anatomy Unit, AIMST University, Kedah, Malaysia
5 R and D Center, Cholayil Private Limited, Chennai, India

Correspondence Address:
M S Ranjith
Associate Professor, Microbiology Unit, Faculty of Medicine, AIMST University, Bedong 08100
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-8490.60581

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Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

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