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Year : 2009  |  Volume : 1  |  Issue : 6  |  Page : 352-358

Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic rats

Department of Biochemistry, S.V.University, Tirupati-517502, AndhraPradesh, India

Correspondence Address:
Ch Apparao
Department of Biochemistry, S.V.University, Tirupati-517502, AndhraPradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-8490.58014

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The methanolic supernatant fraction (MSF) of the aqueous extract of Momordica cymbalaria fruits when given to streptozotocin (STZ) induced diabetic rats showed a significant reduction (65.9%, P<0.001) in fasting blood glucose levels at a dose of 0.5g/kg.b.w. These results were compared to that of glibenclamide, an oral hypoglycemic agent. The active MSF exhibited a dose dependent scavenging activity against 2, 2-diphenly-1-picrylhydrazyl (DPPH) radicals and nitric oxide radicals with an IC50 value of 42.5 and 157.2μg/ml, respectively. Further, the MSF had relatively lower reducing power, compared to that of ascorbic acid. The total phenolic content of the fraction was found to be 132mg/gm of dry fraction. In conclusion, MSF possess antihyperglycemic and antioxidant properties, which could be due to the presence of steroidal glycosides or phenolic compounds.

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