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Year : 2009  |  Volume : 1  |  Issue : 4  |  Page : 175-178

Biological and Chemical Study of Cleome paradoxa B.Br

1 Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
3 Pharmacology Department, National Research Centre, Giza 12622, Egypt

Correspondence Address:
Essam Abdel-Sattar
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

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The methanolic extract of Cleome paradoxa B.Br. and its different fractions (viz. hexane, chloroform, ethyl acetate and n-butanol) were tested for their antidiabetic activities. The ethyl acetate and hexane fractions exhibited the highest activities, which further subjected to chemical investigation. This study resulted in isolation of two compounds from the ethyl acetate fraction and three compounds from the hexane fraction. These compounds were identified using different spectroscopic methods as quercetin, quercetin-3-O-β-D-glucopyranoside (isoquercetrin), α-amyrin, sitgmasterol and sitgmasterol-3-O-β-D-glucpyranoside. The major compound isolated from ethyl acetate fraction, isoquercetrin, was assessed for its antidiabetic activity.

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