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Year : 2009  |  Volume : 1  |  Issue : 2  |  Page : 91-97

New secoiridoids from Ligustrum ovalifolium and their hypotensive activity

Al-Azhar University, Faculty of Pharmacy, Pharmacognosy Department, Cairo, Egypt

Correspondence Address:
Usama Y Shaheen
Al-Azhar University, Faculty of Pharmacy, Pharmacognosy Department, Cairo
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Source of Support: None, Conflict of Interest: None

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New Secoiridoid glucosides 1-5 ; ligustaloside A methyl hemiacetal 1 , ligustaloside B methyl hemiacetal 2 , ligustaloside A dimethyl acetal 3 ligustaloside A butyl-methyl acetal 4 , and ligustaloside B butyl hemiacetal 5 have been isolated from the leaves of Ligustrum ovalifolium L. along with five known secoiridoids; ligustaloside B dimethyl acetal 6 , 10-hydroxy oleuropein 7 , 10-hydroxy ligstroside 8 , oleuropein 9 and ligstroside 10 , one known iridoid; loganin 11 and two known phenethyl alcohol glucosides; 3,4-di hydroxyphenylethyl-β-D-glucoside 12 and p-hydroxyphenylethyl-β-D-glucoside 13. The structures have been elucidated by spectroscopic means including 1H NMR 13C, and DEPT), 2D NMR (COSY, HMQC and HMBC experiments), UV, IR and FAB-MS (positive mode). Both n-BuOH fraction and the isolated new compounds 1-5 were evaluated for their hypotensive activity on experimental animal. The n-BuOH fraction showed good activity; however, the activity of the isolated new compounds 1-5 did not particularly strong.

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