Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 25-34

Effect of the fractions of Coccinia grandis on Ethanol-Induced cerebral oxidative stress in rats

Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata- 700 032, India

Correspondence Address:
T K Chatterjee
Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata- 700 032
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

The present study was aimed at investigating the effect of the various fractions of hydromethanol extract of the leaves of Coccinia grandis (Cucurbitaceae) against ethanol-induced cerebral oxidative stress in rats. The leaves of this species is used in traditional medicine for treating jaundice, bronchitis, skin eruptions, burns, rheumatism, syphilis, gonorrhoea, etc. Cerebral oxidative stress was induced in rats by the administration of 20% ethanol (5 ml/100 g b.w.) for 28 days. The pet-ether (PEF), chloroform (CF), ethylacetate (EAF) and residual (RF) fractions at a dose of 200 mg/kg b.w. were simultaneously administered with ethanol orally for 28 days. Vitamin E at a dose of 100 mg/kg orally was used as the standard. Administration of ethanol resulted in a significant increase in the activities of serum transaminases, alkaline phosphatase, uric acid and lipid levels. In addition, there was a significant elevation in the levels of malondialdehyde and lipid hydroperoxides and a reduction in the activities of enzymatic and non-enzymatic antioxidants in the brain. Simultaneous administration of the fractions prevented the enzymatic leakage and the rise in uric acid and lipid levels. All the fractions (except the residual fraction) prevented the peroxidative damage caused by ethanol, which is evidenced from the improved antioxidant potential. Further, histopathological examination of the brain tissue revealed that the fractions offered significant protection against ethanol toxicity. Among the fractions tested, the chloroform fraction exhibited appreciable antioxidant property, which was almost comparable with the standard Vitamin E. These results suggest that the leaves of Coccinia grandis exhibit significant antioxidant activity in ethanol-treated rats.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded112    
    Comments [Add]    

Recommend this journal