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  Indian J Med Microbiol
 

Figure 2: Anti-pain effect of UP446 in adjuvant induced arthritic rat. A rheumatoid arthritis rat model was induced by injecting Freund's complete adjuvant into subplantar region of left and right hind paw and base of the tail of Wistar rats (n = 12). Animals were administered UP446 (50 mg/kg), ibuprofen (150mg/kg), or vehicle by oral gavage 30 min prior to arthritis induction and each day thereafter for 14 days. Pain sensitivity was measured before adjuvant injection and thereafter on day 3, 5, 7, 9, and 13 after injection. Data are expressed as mean ± SD. * P ≤ 0.001 vs vehicle; ** P ≤ 0.0001 vs vehicle

Figure 2: Anti-pain effect of UP446 in adjuvant induced arthritic rat. A rheumatoid arthritis rat model was induced by injecting Freund's complete adjuvant into subplantar region of left and right hind paw and base of the tail of Wistar rats (n = 12). Animals were administered UP446 (50 mg/kg), ibuprofen (150mg/kg), or vehicle by oral gavage 30 min prior to arthritis induction and each day thereafter for 14 days. Pain sensitivity was measured before adjuvant injection and thereafter on day 3, 5, 7, 9, and 13 after injection. Data are expressed as mean ± SD. * P ≤ 0.001 vs vehicle; ** P ≤ 0.0001 vs vehicle