Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 10  |  Issue : 4  |  Page : 391--396

Protective effect of Ferulago angulata (Schltdl.) Boiss. hydroalcoholic extract against acetic acid-induced colitis in rat: Role of pro-inflammatory cytokines


Fatemeh Farzaei1, Fatemeh Heydarpour2, Mohammad Hosein Farzaei1, Zahra Minush Siavash Haghighi3, Zahra Abbasabadi1, Ehsan Sadeghi2 
1 Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Pathology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran

Correspondence Address:
Dr. Mohammad Hosein Farzaei
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah 6734667149
Iran

Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease with unknown etiology. Ferulago angulata (Schltdl.) Boiss. has been proposed as an efficacious treatment for gastrointestinal ulcers and UC in the traditional Persian medicine. Objective: In the present study, we investigated the possible protective effect of F. angulata (Schltdl.) Boiss. hydroalcoholic extract (FAE) against acetic acid-induced UC in rats. Materials and Methods: The aerial parts of FAE (50, 100, and 200 mg/kg) were administered orally after acetic acid induced-inflammatory bowel disease. On the 3rd day, animals were euthanized by an overdose of ether inhalation and the abdomen was rapidly dissected for macroscopic, histological, and biochemical (tumor necrosis factor [TNF]-α, interleukin-1β [IL-1β]) analyses. Results: All doses of F. angulata (Schltdl.) Boiss. extract ameliorated acetic acid-induced macroscopic and microscopic scores, except for 50 mg/kg. Furthermore, our observations were accompanied by a significant (P < 0.05) suppression in the elevated amount of IL-1β and TNF-α. Conclusion: These findings demonstrated the beneficial effect of hydroalcoholic extract of F. angulata (Schltdl.) Boiss. in acetic acid-induced ulcerative lesions via anti-inflammatory, immunomodulatory, and mucosal healing properties. F. angulata (Schltdl.) Boiss. possesses promising protective function on colitis. Abbreviations Used: IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn's disease; TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β; PMN: Polymorphonuclear; NO: Nitric oxide; FAE: Ferulago angulata (Schltdl.) Boiss. hydroalcoholic extract; COX: Cyclooxygenase.


How to cite this article:
Farzaei F, Heydarpour F, Farzaei MH, Haghighi ZM, Abbasabadi Z, Sadeghi E. Protective effect of Ferulago angulata (Schltdl.) Boiss. hydroalcoholic extract against acetic acid-induced colitis in rat: Role of pro-inflammatory cytokines.Phcog Res 2018;10:391-396


How to cite this URL:
Farzaei F, Heydarpour F, Farzaei MH, Haghighi ZM, Abbasabadi Z, Sadeghi E. Protective effect of Ferulago angulata (Schltdl.) Boiss. hydroalcoholic extract against acetic acid-induced colitis in rat: Role of pro-inflammatory cytokines. Phcog Res [serial online] 2018 [cited 2019 May 23 ];10:391-396
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2018;volume=10;issue=4;spage=391;epage=396;aulast=Farzaei;type=0