Year : 2017 | Volume
: 9 | Issue : 1 | Page : 65--68
New cytotoxic cembranoid from indonesian soft coral Sarcophyton sp.
Hedi Indra Januar1, Neviaty Putri Zamani3, Dedi Soedharma3, Ekowati Chasanah2
1 Department of Biotechnology, Indonesian Research and Development Center for Marine and Fisheries Products Processing and Biotechnology, Jakarta; Department of Marine Science, Faculty of Fisheries and Marine Science, Bogor Agricultural University, Bogor, Indonesia
2 Department of Biotechnology, Indonesian Research and Development Center for Marine and Fisheries Products Processing and Biotechnology, Jakarta, Indonesia
Context: Sarcophyton is a soft coral species that contains various secondary metabolites with cytotoxic activity. The production of cytotoxic compounds in soft corals is suggested as their allelochemical to win space competition. Therefore, if a particular soft coral species dominates a reef area, it may suggest to contain interesting bioactive compounds. Aims: This research aimed to characterize the cytotoxic compounds in dominant soft coral species (Sarcophyton sp.) on the reef at the Western side of Mahengetang Island, Indonesia. Subjects and Methods: Isolation of cytotoxic compounds through ethanol extracts had been done with preparative high-performance liquid chromatography and bioassay-guided fractionation by MCF-7 (breast) cancer cell lines. The structures of each cytotoxic compounds were elucidated on the basis of mass and nuclear magnetic resonance spectroscopic studies. Results: Elucidation through all compounds found a new cembranoid, namely, 2-hydroxy-crassocolide E (1), alongside with 5 known cembranoids; sarcophytoxide (2), sarcrassin E (3), 3,7,11-cembreriene-2,15-diol (4), 11,12-epoxy-Sarcophytol A (5), and sarcophytol A (6). All of these cembranoids were showed to inhibit the growth of MCF-7 (breast) cancer, with 50% inhibition of tumor cell lines growth lower than 30 mg/L. Conclusions: Results of this study suggest that a soft coral species which dominate a reef area is a potential source for various bioactive compounds.
Hedi Indra Januar
KS Tubun Petamburan VI Street, Slipi, Jakarta
|How to cite this article:|
Januar HI, Zamani NP, Soedharma D, Chasanah E. New cytotoxic cembranoid from indonesian soft coral Sarcophyton sp. Phcog Res 2017;9:65-68
|How to cite this URL:|
Januar HI, Zamani NP, Soedharma D, Chasanah E. New cytotoxic cembranoid from indonesian soft coral Sarcophyton sp. Phcog Res [serial online] 2017 [cited 2020 Sep 28 ];9:65-68
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2017;volume=9;issue=1;spage=65;epage=68;aulast=Januar;type=0