Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 9  |  Issue : 1  |  Page : 21--26

Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats


GM Gururaja, Deepak Mundkinajeddu, A Senthil Kumar, Shekhar Michael Dethe, J Joshua Allan, Amit Agarwal 
 Research Scholar, Manipal University, Manipal; Natural Remedies R and D Centre, Bengaluru, Karnataka, India

Correspondence Address:
Shekhar Michael Dethe
Natural Remedies R and D Centre, No. 5B, Veerasandra Industrial Area, 19th km, Hosur Road, Electronic City, Bengaluru - 560 100, Karnataka
India

Introduction: Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined. Materials and Methods: The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-β-D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography. Results and Discussion: Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-β-D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract. Conclusions: The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels.


How to cite this article:
Gururaja G M, Mundkinajeddu D, Kumar A S, Dethe SM, Allan J J, Agarwal A. Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats.Phcog Res 2017;9:21-26


How to cite this URL:
Gururaja G M, Mundkinajeddu D, Kumar A S, Dethe SM, Allan J J, Agarwal A. Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats. Phcog Res [serial online] 2017 [cited 2020 Oct 1 ];9:21-26
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2017;volume=9;issue=1;spage=21;epage=26;aulast=Gururaja;type=0