Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 8  |  Issue : 2  |  Page : 112--117

UP1304, a botanical composition containing two standardized extracts of Curcuma longa and Morus alba, mitigates pain and inflammation in Adjuvant-induced arthritic rats


Mesfin Yimam1, Young-Chul Lee2, Breanna Moore1, Ping Jiao1, Mei Hong1, Jeong-Bum Nam2, Mi-Ran Kim2, Tae-Woo Kim2, Hyun-Jin Kim2, Eu-Jin Hyun2, Min Chu1, Lidia Brownell1, Qi Jia1 
1 Unigen Inc., Seattle, WA-98121, USA
2 Unigen Inc., Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Korea

Correspondence Address:
Mesfin Yimam
Unigen, Inc., 3005 First Avenue, Seattle, WA 98121
USA

Background: Though, the initial etiologies of arthritis are multifactorial, clinically, patients share pain as the prime complaints. Present day pain relief therapeutics heavily relies on the use of prescription and over the counter nonsteroidal anti-inflammatory drugs as the first line of defense where their long-term usage causes gastrointestinal and cardiovascular-related side effects. Hence, the need for evidence-based safer and efficacious alternatives from natural sources to overcome the most prominent and disabling symptoms of arthritis is an overdue. Here, we evaluated the anti-inflammatory and analgesic effect of UP1304, a composition that contains a standardized blend of two extracts from the rhizome of Curcuma longa and the root bark of Morus alba in adjuvant-induced arthritis models in rats. Materials and Methods: The anti-inflammatory and analgesic effects of the botanical composition were demonstrated in adjuvant-induced arthritis models in rats with oral dose ranges of 50–200 mg/kg. Ibuprofen at a dose of 100 mg/kg was used as a reference compound. Ex vivo sulfated glycosaminoglycan inhibition assays were performed. Results: Statistically significant improvements in pain resistance, suppression of paw edema and ankle thickness were observed in animals treated with UP1304 compared to vehicle-treated diseased rats. These results were similar to those achieved by ibuprofen treatment. Inhibitions of proteoglycan degradation were observed in a range of 37.5–61.7% for concentration of UP1304 at 50–200 μg/mL when compared to interleukin-1α-exposed untreated explants. Conclusions: These data suggest that UP1304, for its analgesic and anti-inflammatory effects, could potentially be considered agent of botanical origin for the improvement of arthritis associated symptoms.


How to cite this article:
Yimam M, Lee YC, Moore B, Jiao P, Hong M, Nam JB, Kim MR, Kim TW, Kim HJ, Hyun EJ, Chu M, Brownell L, Jia Q. UP1304, a botanical composition containing two standardized extracts of Curcuma longa and Morus alba, mitigates pain and inflammation in Adjuvant-induced arthritic rats.Phcog Res 2016;8:112-117


How to cite this URL:
Yimam M, Lee YC, Moore B, Jiao P, Hong M, Nam JB, Kim MR, Kim TW, Kim HJ, Hyun EJ, Chu M, Brownell L, Jia Q. UP1304, a botanical composition containing two standardized extracts of Curcuma longa and Morus alba, mitigates pain and inflammation in Adjuvant-induced arthritic rats. Phcog Res [serial online] 2016 [cited 2019 Oct 19 ];8:112-117
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2016;volume=8;issue=2;spage=112;epage=117;aulast=Yimam;type=0