Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 1  |  Page : 17--21

Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum


Mahmoud I Nassar1, El-Sayed A Aboutabl2, Dina M Eskander1, Mary H Grace1, Ezzel-Din A EL-Khrisy1, Amany A Sleem3 
1 Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Egypt
2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Dokki, Cairo, Egypt
3 Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt

Correspondence Address:
Mahmoud I Nassar
Department of Chemistry of Natural Compounds, National Research Centre, 12622 Dokki,Cairo
Egypt

Background: Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation. Materials and Methods: Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves. Results: Identification of a new flavone glycoside, acacetin 8-C-β-D- glucopyranosy l-(1→2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD 50 ) revealed that the different extracts were safe.


How to cite this article:
Nassar MI, Aboutabl ESA, Eskander DM, Grace MH, EL-Khrisy EDA, Sleem AA. Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum.Phcog Res 2013;5:17-21


How to cite this URL:
Nassar MI, Aboutabl ESA, Eskander DM, Grace MH, EL-Khrisy EDA, Sleem AA. Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum. Phcog Res [serial online] 2013 [cited 2020 Apr 4 ];5:17-21
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=1;spage=17;epage=21;aulast=Nassar;type=0