Pharmacognosy Research

SHORT COMMUNICATION
Year
: 2012  |  Volume : 4  |  Issue : 2  |  Page : 123--126

In vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.


Priyanka Yadav1, Aditya Ganeshpurkar1, Gopal Rai2 
1 Department of Pharmacology, Shri Ram Institute of Technology -Pharmacy, Jabalpur, Madhya Pradesh, India
2 Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India

Correspondence Address:
Gopal Rai
Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh
India

Objective: This study was undertaken to study in vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Materials and Methods: Total phenolic and flavonoid contents from extract was quantified and H + -K + ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. Results: Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. Conclusions: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.


How to cite this article:
Yadav P, Ganeshpurkar A, Rai G. In vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Phcog Res 2012;4:123-126


How to cite this URL:
Yadav P, Ganeshpurkar A, Rai G. In vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Phcog Res [serial online] 2012 [cited 2020 Aug 10 ];4:123-126
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2012;volume=4;issue=2;spage=123;epage=126;aulast=Yadav;type=0