Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 6  |  Page : 364--367

Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves


Manjit Singh1, Vijender Kumar1, Ishpinder Singh2, Vinod Gauttam3, Ajudhia Nath Kalia3 
1 Department of Pharmacognosy, L.L.R. College of Pharmacy, Moga, Punjab-142001, India
2 Department of Pharmacognosy, Adesh College of Pharmacy, Bathinda - 151001, Punjab, India
3 Department of Pharmacognosy, I.S.F. College of Pharmacy, Moga - 142 001, Punjab, India

Correspondence Address:
Manjit Singh
Department of Pharmacognosy, L.L.R. College of Pharmacy, Moga - 142 001, Punjab
India

Background: The objective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL) (Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin. Methods: Aqueous extract of the leaves was prepared by cold maceration. Results: The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P < 0.05) inhibition of paw oedema, 37.5% and 54.0% on 4 th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9% and 43.0% on 4 th day at the doses of 200 and 400 mg/kg, respectively. Conclusion: The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.


How to cite this article:
Singh M, Kumar V, Singh I, Gauttam V, Kalia AN. Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves.Phcog Res 2010;2:364-367


How to cite this URL:
Singh M, Kumar V, Singh I, Gauttam V, Kalia AN. Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves. Phcog Res [serial online] 2010 [cited 2019 Aug 24 ];2:364-367
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2010;volume=2;issue=6;spage=364;epage=367;aulast=Singh;type=0