Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 5  |  Page : 313--317

A study of the anti-inflammatory effect of the leaves of Psidium guajava Linn. on experimental animal models


Sarmistha Dutta, Swarnamoni Das 
 Department of Pharmacology, Assam Medical College and Hospital, Dibrugarh - 786 002, Assam, India

Correspondence Address:
Sarmistha Dutta
Department of Pharmacology, Assam Medical College and Hospital, Dibrugarh - 786 002, Assam
India

Introduction : The aim is to study the anti-inflammatory effect of the ethanolic extract of the leaves of Psidium guajava (PGE) on experimental animal models. Materials and Methods : Fresh leaves were collected, air-dried, powdered, and percolated in 95% ethanol. Acute toxicity test was done according to OECD guidelines. Four groups of animals of either sex, weighing 150-200g of the species Rattus norvegicus were taken for the study (n = 6). Group A was taken as control (3% gum acacia in 10 mL/kg body weight), Group B as test group (PGE 250 mg/kg body weight), Group C as test group (PGE 500 mg/kg body weight), and Group D as standard (Aspirin 100 mg/kg body weight). The animals were studied for acute inflammation by Carrageenan-induced rat paw edema, subacute inflammation by Granuloma pouch method, and chronic inflammation by Freund«SQ»s adjuvant-induced arthritis method. Statistical analysis was done by one-way analysis of variance followed by multiple comparison tests. Results : In acute inflammation, there was significant inhibition of paw edema in Groups B, C, and D in comparison with Group A (P < 0.05). In subacute inflammation, there was significant inhibition of exudate formation in Groups B, C, and D in comparison to Group A (P < 0.05). In chronic inflammation, there was significant inhibition of paw edema and inhibition of weight reduction in Groups B, C, and D compared with Group A. Downregulation of arthritis index was also significant in Groups B, C, and D in comparison with Group A (P < 0.05). Conclusion : The ethanolic extract of PGE has significant anti-inflammatory activity.


How to cite this article:
Dutta S, Das S. A study of the anti-inflammatory effect of the leaves of Psidium guajava Linn. on experimental animal models.Phcog Res 2010;2:313-317


How to cite this URL:
Dutta S, Das S. A study of the anti-inflammatory effect of the leaves of Psidium guajava Linn. on experimental animal models. Phcog Res [serial online] 2010 [cited 2020 Jul 8 ];2:313-317
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2010;volume=2;issue=5;spage=313;epage=317;aulast=Dutta;type=0