Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 4  |  Page : 215--220

Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract


Geethaa Sahgal1, Surash Ramanathan1, Sreenivasan Sasidharan2, Mohd. Nizam Mordi1, Sabariah Ismail1, Sharif Mahsufi Mansor1 
1 Center for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia
2 Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia

Correspondence Address:
Sreenivasan Sasidharan
Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia
Malaysia

Background: The seeds of Swietenia mahagoni have been applied in folk medicine for the treatment of hypertension, diabetes, malaria, amoebiasis, cough, chest pain, and intestinal parasitism. Here we are the first to report on the toxicity of the Swietenia mahagoni crude methanolic (SMCM) seed extract. Methods: SMCM seed extract has been studied for its brine shrimp lethality and acute oral toxicity, in mice. Results: The brine shrimp lethality bioassay shows a moderate cytotoxicity at high concentration. The LC50 for the extract is 0.68 mg/ml at 24 hours of exposure. The LD50 of the SMCM seed extract for acute oral toxicity in mice is greater than 5000 mg/kg. Conclusion: This study demonstrates that Swietenia mahagoni crude methanolic seed extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.


How to cite this article:
Sahgal G, Ramanathan S, Sasidharan S, Mordi M, Ismail S, Mansor SM. Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract.Phcog Res 2010;2:215-220


How to cite this URL:
Sahgal G, Ramanathan S, Sasidharan S, Mordi M, Ismail S, Mansor SM. Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract. Phcog Res [serial online] 2010 [cited 2020 Aug 11 ];2:215-220
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2010;volume=2;issue=4;spage=215;epage=220;aulast=Sahgal;type=0