Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 3  |  Page : 175--180

Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage


MA Ibrahim1, AB Aliyu2, AB Sallau1, M Bashir1, I Yunusa3, TS Umar1 
1 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
2 Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
3 Department of Food Science and Technology, Kano University of Science and Technology, Wudil, Nigeria

Correspondence Address:
M A Ibrahim
Department of Biochemistry, Ahmadu Bello University, Zaria
Nigeria

The in vitro and in vivo antitrypanosomal effects of the ethanol extract of Senna occidentalis leaf were investigated. The crude extract exhibited an in vitro activity against Trypanosoma brucei brucei as it completely eliminated parasites«SQ» motility within 10 minutes postincubation with 6.66 mg/ml of effective extract concentration. The extract was further used to treat experimentally T. brucei brucei infected rats at concentrations of 100 and 200 mg/kg body weight, beginning on day 5 post infections (p.i.). At the termination of the experiment on Day 11 p.i., the extract significantly (P < 0.05) kept the parasitemia lower than was recorded in the infected untreated rats. All the infected animals developed anemia, the severity of which was significantly (P < 0.05) ameliorated by the extract treatment. The infection caused significant (P < 0.05) increases in serum alanine and aspartate aminotransferases as well as serum urea and creatinine levels. However, treatment of infected animals with the extract significantly (P < 0.05) prevented the trypanosome-induced increase in these biochemical indices. Furthermore, the T. brucei infection caused hepatomegaly and splenomegaly that were significantly (P < 0.05) ameliorated by the extract administration. It was concluded that orally administered ethanol extract of S. occidentalis leaf possessed anti-T. brucei brucei activity and could ameliorate the disease-induced anemia and organ damage.


How to cite this article:
Ibrahim M A, Aliyu A B, Sallau A B, Bashir M, Yunusa I, Umar T S. Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage.Phcog Res 2010;2:175-180


How to cite this URL:
Ibrahim M A, Aliyu A B, Sallau A B, Bashir M, Yunusa I, Umar T S. Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage. Phcog Res [serial online] 2010 [cited 2020 Oct 1 ];2:175-180
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2010;volume=2;issue=3;spage=175;epage=180;aulast=Ibrahim;type=0