Pharmacognosy Research

RESEARCH ARTICLE
Year
: 2009  |  Volume : 1  |  Issue : 6  |  Page : 392--395

Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats


Gidado Abubakar1, A Ameh Danladi2, E Atawodi Sunday2, Ibrahim Sani1 
1 Department of Biochemistry, University of Maiduguri, Maiduguri, Nigeria
2 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria

Correspondence Address:
Gidado Abubakar
Department of Biochemistry, University of Maiduguri, Maiduguri
Nigeria

The antidiabetic and possible toxicity of ethanolic extract of the leaf of Nauclea latifolia was studied in streptozotocin-induced diabetic rats. Doses of 100, 200 and 400mg/kg body weight were given orally to the STZ-induced diabetic rats daily for 45 days. All the doses showed significant hypoglycaemic effect. The effect is however not dose dependent. Indices of liver and kidney functions studied were not statistically affected by the extract administration. Ethanolic extract of the leaf of N. latifolia thus exhibited antidiabetic action in STZ-induced diabetic rats with minimal toxicity.


How to cite this article:
Abubakar G, Danladi A A, Sunday E A, Sani I. Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats.Phcog Res 2009;1:392-395


How to cite this URL:
Abubakar G, Danladi A A, Sunday E A, Sani I. Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats. Phcog Res [serial online] 2009 [cited 2020 Aug 11 ];1:392-395
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2009;volume=1;issue=6;spage=392;epage=395;aulast=Abubakar;type=0