@article {1228, title = {In silico and Biological Screening of Phytochemicals against NMDA Receptor for Alzheimer{\textquoteright}s Disease Therapeutics}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {244-253}, type = {Original Article}, chapter = {244}, abstract = {

Background: Alzheimer{\textquoteright}s Disease (AD), characterized by irreversible neurodegeneration and cognitive decline, lacks a definitive cure, and current medications merely alleviate symptoms. Cognitive manifestations in AD are linked to disrupted glutamatergic neurotransmission, where β-Amyloid (A) accumulation at specific synapses interacts with glutamine synthetase, causing enzyme inactivation and subsequent NMDA signalling impairment. Dysregulation of glutamine synthetase leads to NMDA receptor hyper activation, resulting in neuronal damage and cell death. Aim: The focus of this investigation is on N-Methyl D-Aspartate (NMDA) receptors, which belong to the ionotropic glutamate receptor family and play vital roles in various physiological and pathological processes such as neuron development, synaptic plasticity, and central nervous system learning and memory. This study seeks to analyze target data to differentiate between effective and ineffective options for virtual screening. Utilizing this information, the study aims to generate a novel or enhanced reaction product. Materials and Methods: Computational embedding was employed to explore interactions between NMDA receptors and phytoconstituents of selected plants, including Amla, Shankhapushpi, Giloy, Ashwagandha, and Turmeric. ADMET descriptions for well-known botanical compounds were also scrutinized. Results: Structural analysis of 75 compounds derived from selected phytochemicals was conducted based on molecular properties. Key compounds were identified, and additional ADMET properties were evaluated. Quercetin emerged as the top-ranking compound based on shear score, shear strength, and molecular interactions with NMDA receptors. Conclusion: This computational study identifies specific plants as potential NMDA receptor antagonists, offering promise for mitigating Alzheimer{\textquoteright}s disease symptoms in the future.

}, keywords = {ADMET descriptions, Alzheimer{\textquoteright}s disease, Computational embedding, Dock ligands, Molecular docking, N-methyl-D-aspartate-receptor, Quercetin.}, doi = {10.5530/pres.16.2.31}, author = {Bhushan Arun Baviskar and Sharada Laxman Deore and Bhavana Ashok Shende and Somshekhar Khadabadi and Anjali Ashokrao Kide} } @article {1211, title = {Formulation of Herbal Candies Containing Giloy Satva: A Nutritious and Palatable Herbal Confectionery Option}, journal = {Pharmacognosy Research}, volume = {16}, year = {2023}, month = {December 2023}, pages = {146-151}, type = {Original Article}, chapter = {146}, abstract = {

Background: Giloy (Tinospora cordifolia) is an Ayurvedic herb known for its numerous health benefits. Objectives: In this study, we aimed to prepare Giloy Satva candy. Materials and Methods: The candy was prepared by incorporating Giloy Satva in various concentrations batch wise, with other natural ingredients to enhance its palatability and therapeutic value. Physicochemical and therapeutic evaluation of the Giloy Satva candies involved assessing parameters such as moisture content, ash value, Total Soluble Solids (TSS), phytochemical screening, pH, sensory evaluation and Antioxidant assay. Results and Discussion: The finalized batch candy exhibited a desirable moisture content (7.44{\textpm}0.08\%), ash value (1.26{\textpm}0.67\%), and TSS (69.05 {\textdegree}Brix). The pH of the candy was found to be within the acceptable range (4.8{\textpm}0.30), ensuring its stability and suitability for consumption. In sensory evaluation, the candy received positive feedback for its taste, texture, aroma, and overall acceptability. Furthermore, the antioxidant activity of the Giloy Satva candy was determined using in vitro DPPH assays. The candy exhibited significant antioxidant activity (53.23{\textpm}0.23 μg/mL), indicating its potential to combat oxidative stress and associated health issues. Conclusion: In conclusion, the Giloy Satva candy demonstrated promising physicochemical properties, excellent sensory attributes, and potent antioxidant activity. The developed candy formulation could serve as a convenient and palatable herbal preparation, offering the benefits of Giloy in an easily consumable form. Further investigations, including stability studies and clinical trials, are warranted to explore its therapeutic potential and commercial viability.

}, keywords = {Candy, Giloy satva, Hepatoprotective., Immunomodulation, T. crispa}, doi = {10.5530/pres.16.1.18}, author = {Sharada Laxman Deore and Bhushan Arun Baviskar and Anjali Ashok Kide and Bhavana Ashok Shende and Aditya Gachake and Dwiptesha Dahake} }