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ORIGINAL ARTICLE
Year : 2020  |  Volume : 12  |  Issue : 3  |  Page : 285-298

Comparative botanical and phytochemical studies of ambiguous medicinal plant species of Wedelia and Eclipta (Fam. Asteraceae) used in ASU systems of medicine with special reference to in-silico screening of hepatoprotective potential of marker wedelolactone with acetaminophen targets


1 Department of Botany, Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, (CCRAS, Ministry of AYUSH, Government of India, New Delhi), Anna Hospital Campus, Chennai, Tamil Nadu, India
2 Department of Pharmacology, Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, (CCRAS, Ministry of AYUSH, Government of India, New Delhi), Anna Hospital Campus, Chennai, Tamil Nadu, India
3 Department of Chemistry, Siddha Central Research Institute, (CCRS, Ministry of AYUSH, Government of India, Chennai), Anna Hospital Campus, Chennai, Tamil Nadu, India
4 Department of Clinical Research, Siddha Central Research Institute, (CCRS, Ministry of AYUSH, Government of India, Chennai), Anna Hospital Campus, Chennai, Tamil Nadu, India
5 Department of Botany, Siddha Central Research Institute, (CCRS, Ministry of AYUSH, Government of India, Chennai), Anna Hospital Campus, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. R Arunadevi
Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, (CCRAS, Ministry of AYUSH, Government of India, New Delhi), Anna Hospital Campus, Arumbakkam, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pr.pr_11_20

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Context: In traditional medicine, Kesaraja (Ayurveda) or Manjal karisali (Siddha) is effective for jaundice. Aim: Three species of Asteraceae need to be studied for their therapeutic superiority of their intended claim. They are Wedelia chinensis (Osbeck) Merr. Philipp J., Wedelia trilobata (L.) Hitchc. and Eclipta prostrata (L.) L. (Asteraceae). The present study aimed to screen and characterize the potential species for therapeutic purpose. Materials and Methods: The whole plants, W. chinensis (Osbeck) Merr. Philipp J., W. trilobata (L.) Hitchc. and Eclipta prostrata (L.) (Asteraceae) were collected and botanically identified. Preliminary phytochemical analysis and high-performance thin-layer chromatography finger printing with marker wedelolactone were done for the ethanolic extracts of these plants. Botanical and pharmacognostical diagnostic characters of the plants based on macro-morphological, micro-morphological and powder microscopical characterization were worked out. Comparative in-vitro antioxidant potential of ethanolic extracts of these plant species was carried out. Using ADMET SAR software, the pharmacokinetics of wedelolactone were predicted. Using Autodock 4.2 software, the binding energy of wedelolactone on targets of acetaminophen-induced hepatotoxicity namely PPAR-α, AMPK, JNK-1, EGFR, Nrf2, ALT, ALP, GGT, CAR, Frizzled receptor, FXR, ERK1, LXR, mitochondrial glutamate dehydrogenase, p53, mTOR C1, CYP1A2, CYP2E1, 5-lipoxygenase, thrombin, UCP1, GSK1, RXR and PXR was predicted. Results: All the three plant species were pharmacognostically and chemically different. W. chinensis was found to possess more antioxidant potential than the other two plants. The marker compound wedelolactone was not detected in W. trilobata. Wedelolactone passed the Lipinski's rule of five, and the docking analysis of wedelolactone confirmed high binding affinity toward PPAR-α, AMPK, Nrf2, CYP2E1, EGFR, JNK1, UCP-2, thrombin, 5-lipoxygenase, mTORC1, RXR, FXR, LXR, Frizzled receptor, GDH and Erk-1. Conclusion: Based on the above observations, we conclude that the presence of marker compound wedelolactone might have attributed the potency of W. chinensis and E. prostrata in counteracting acetaminophen toxicity when compared with W. trilobata.


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