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ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 4  |  Page : 356-362

Effect of geraniol and clarithromycin combination against gastric ulcers induced by acetic acid and Helicobacter pylori in rats


1 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
2 Department of Pathology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia

Correspondence Address:
Dr. Subrat Kumar Bhattamisra
Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pr.pr_21_19

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Background: Previous work showed geraniol to have anti-Helicobacter pylori activity in vivo and in vitro. Further, it has augmented the anti-H. pylori activity of clarithromycin in vitro. Objective: Geraniol and clarithromycin combination was investigated for anti-ulcer and anti-H. pylori activity in rats. Materials and Methods: Ulcers were induced by injecting acetic acid into the subserosal layer of the stomach followed by intragastric inoculation of H. pylori for 7 days. Geraniol (30 mg/kg) and a drug combination (geraniol, 30 mg/kg and clarithromycin, 25 mg/kg) were administered twice daily for 14 days, and parameters were measured at the end of treatment. Results: Geraniol alone or in combination with clarithromycin significantly (P < 0.05) lowered the ulcer index and improved the curative ratio. Histopathological examination showed a significant reduction (P < 0.05) in the ulcer score in the geraniol and geraniol–clarithromycin treated animals compared with the ulcer controls. Both the treatment groups showed significant (P < 0.05) increase in the glutathione level and reduction in the malondialdehyde, interleukin 6, and tumor necrosis factor-α level in the gastric mucosa compared to control group. Both produced a 50% reduction in the rapid urease test, which is further confirmed using modified Giemsa staining. Conclusion: Geraniol, alone or in combination with clarithromycin, showed a significant ulcer healing effect which was associated with anti-H. pylori, anti-inflammatory, and antioxidant effects in the gastric mucosa. However, the effects of the geraniol and clarithromycin combination were not significantly different from the effects of geraniol alone in this model.


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