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Year : 2019  |  Volume : 11  |  Issue : 4  |  Page : 339-345

Chromatographic profiles, anti-inflammatory, and cytotoxicity potential of extracts of Banisteriopsis pubipetala (A. Juss)

1 Department of General Biology, Montes Claros State University, Professor Darcy Ribeiro University Campus, Montes Claros, Minas Gerais, Brazil
2 Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Minas Gerais, Brazil
3 Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Minas Gerais; Federal University of Espírito Santo, North University Center of Espírito Santo, Sao Mateus, Espírito Santo, Brazil

Correspondence Address:
Dr. Vanessa de Andrade Royo
Universidade Estadual De Montes Claros, Campus Universitário Professor Darcy Ribeiro, Av Ruy Braga S/N, Cep 39401-089, Vila Mauriceia, Montes Claros, Minas Gerais
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_71_19

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Background: Banisteriopsis pubipetala is a little-studied species belonging to the same genus of B. caapi, which stands out for the bioactive compounds known to be important in the degenerative diseases treatment. Objective: The objective is to analyze the anti-inflammatory and cytotoxic potential and chromatographic profile of the extracts of B. pubipetala. Materials and Methods: The investigation of the chromatographic profile was performed through high-performance liquid chromatography diode-array detector. Cell viability was determined by a quantitative colorimetric assay with 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide. In the pharmacological tests, interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), IL-10, and nitric oxide (NO) levels in cell culture supernatants were performed. Results: In the leaf were observed nine major compounds and in the stem five major compounds. The extracts of B. pubipetala demonstrated concentration-dependent behavior regarding cytotoxicity. The fraction in dichloromethane had inhibitory concentration of 50% (IC50) = 67.39 μg/mL whereas the extract in ethyl acetate had IC50 =103.37 μg/mL. The results showed that extracts significantly reduced the production of IL-6 and TNF-α by cells 3T3 cells, however increased the production of IL-10 and NO. Conclusion: The results of the tests indicate that the extracts of B. pubipetala evaluated have potential anti-inflammatory properties and may promote the regulation of inflammation levels.

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