Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2019  |  Volume : 11  |  Issue : 3  |  Page : 279-282

In silico anti-preeclampsia potential of phytochemical found in Ficus elastica

1 Department of Public Health, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia
2 Department of Biomedical Science, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia
3 Department of Medical Science, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia
4 Department of Midwifery, Faculty of Health Science and Pharmacy, Adiwangsa Jambi University, Jambi, Indonesia
5 Medical Research Center, Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia
6 Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, Indonesia

Correspondence Address:
Dr. Chrismis Novalinda Ginting
Faculty of Medicine, Universitas Prima Indonesia, Jl. Ayahanda No. 68A,Medan 20118
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pr.pr_176_18

Rights and Permissions

Context: Preeclampsia (PE) is a disorder found in pregnant women characterized by high blood pressure and high protein content in urine. Delivery of the baby and placenta is the most recommended treatment in PE, but treating its symptoms (hypertension) has also been recommended. Aims: This study is intended to assess the major compounds found in Ficus elastica leaf as anti-PE using an in silico approach. Settings and Design: All in silico analysis was performed under default settings. Subjects and Methods: Antioxidant and anti-inflammatory probability values of the five compounds in F. elastica leaf are predicted using quantitative structure–activity relationship. The possible binding mode of the compounds is predicted using molecular docking. Results: Based on the structural properties, compounds found in F. elastica leaf have a high probability activity as an antioxidant and anti-inflammatory. The compounds found in F. elastica , especially morin, have the highest binding affinity toward beta-adrenergic receptor 2 (ADRB2) with similar intermolecular interaction with its known inhibitor. Conclusions: The compounds found in F. elastica may be beneficial for treating PE through its possible antioxidant and anti-inflammatory properties and inhibition of ADRB2.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded5    
    Comments [Add]    

Recommend this journal