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ORIGINAL ARTICLE
Year : 2018  |  Volume : 10  |  Issue : 1  |  Page : 44-48

In vitro Evaluation of Antioxidant Potential of Isolated Compounds and Various Extracts of Peel of Punica granatum L.


1 Research Scholar, Karpagam University, Karpagam Academy of Higher Education Coimbatore, Tamil Nadu; R and D Centre, Natural Remedies Pvt. Ltd, Bengaluru, Karnataka, India
2 Research Scholar, Karpagam University, Karpagam Academy of Higher Education; Department of Environmental Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India
3 R and D Centre, Natural Remedies Pvt. Ltd, Bengaluru, Karnataka, India

Correspondence Address:
Ms. Janani Jacob
Natural Remedies Pvt. Ltd., 5B, Veerasandra Industrial Area, Hosur Road, Bengaluru - 560 100, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pr.pr_36_17

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Background: Punica granatum L. (Lythraceae) peel has been proven to exhibit widespread pharmacological application against multitude of diseases due to the presence of bioactive principles. Objective: The objective is to isolate the bioactive compounds from the pericarp of P. granatum and to evaluate the antioxidant activity of various extracts. Materials and Methods: Dried peel of P. granatum was extracted with aqueous acetone and chromatographed on Diaion HP-20. Enriched fractions were rechromatographed on Sephadex LH-20 and purified on preparative high-performance liquid chromatography to identify individual compounds. The dried peel was extracted with different solvents to evaluate the antioxidant activity of the extracts. Results: On the chemical investigation, three compounds were isolated and characterized as punicalagin, 2,3-(S)-hexahydroxydiphenoyl-D-glucose, and punicalin, using various spectroscopic techniques. Conclusion: Results indicate that the isolated compounds have possessed antioxidant activity, and aqueous, methanol, and aqueous acetone extract showed significant scavenging of 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) radicals.


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