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ORIGINAL ARTICLE
Year : 2017  |  Volume : 9  |  Issue : 3  |  Page : 247-252

Ameliorative effect of curcumin on olanzapine-induced obesity in Sprague-Dawley rats


1 Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Kedah, Malaysia
2 Department of Pathology, Faculty of Medicine, AIMST University, Kedah, Malaysia

Correspondence Address:
Subramani Parasuraman
Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pr.pr_8_17

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Objective: To evaluate the effect of curcumin on olanzapine-induced obesity in rats. Materials and Methods: Sprague-Dawley (SD) rats were used for experiments. The animals were divided into six groups, namely, normal control, olanzapine control, betahistine (10 mg/kg), and curcumin 50, 100, and 200 mg/kg treated groups. Except the normal control group, all other animals were administered with olanzapine 4 mg/kg intraperitoneally to induce obesity. The drugs were administered once daily, per oral for 28 days. During the experiment, body weight changes and behavior alterations were monitored at regular intervals. At the end of the experiment, blood sample was collected from all the experimental animals for biochemical analysis. Part of the liver and kidney tissues was harvested from the sacrificed animals and preserved in neutral formalin for histopathological studies. Results: Curcumin showed a significant reduction in olanzapine-induced body weight gain on the rats and improved the locomotor effects. The effect of curcumin on olanzapine-induced body weight gain is not comparable with that of betahistine. Conclusion: This study has shown metabolic alteration effect of curcumin on olanzapine, an antipsychotic drug, treated SD rats.


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