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ORIGINAL ARTICLE
Year : 2016  |  Volume : 8  |  Issue : 2  |  Page : 142-146

Antimicrobial, Anti-inflammatory and antioxidant activities of Jatropha multifida L. (Euphorbiaceae)


1 Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA); Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM); Centre de Recherche en Agriculture Biologique et Substances Naturelles (CRABISNA), Togo
2 Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA); Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Togo
3 Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM); Laboratoire de Physiologie et de Pharmacologie, Faculté des Sciences, Université de Lomé, B.P. 1515, Togo

Correspondence Address:
Kokou Anani
Laboratoire de Microbiologie et de Controle de Qualite des Denrees Alimentaires, Ecole Superieure des Techniques Biologiques et Alimentaires, Universite de LomLomé, B.P. 1515, Lomé, Togo. Centre de Recherche et de Formation sur les Plantes Medicinales, Universite de LomLomé, B.P. 1515, LomLomé
Togo
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.172657

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Background: Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds. Objective: This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract. Materials and Methods: The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl-1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity. Results: The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa. The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity. Conclusion: J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine.


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