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ORIGINAL ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 5  |  Page : 34-38

Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats


1 Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
2 Animal Physiology Laboratory, Department of Animal Science, University of Ibadan, Ibadan, Oyo State, Nigeria

Correspondence Address:
Oluwatoyin A Adeyemo-Salami
Department of Biochemistry, College of Medicine, University of Ibadan, U.I.P.O. Box 9761, 200005, Ibadan, Oyo State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.150522

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Background: Paullinia pinnata is a medicinal plant used for the treatment of various diseases, including anemia in West Africa. Aim: This study was carried out to investigate the effect of increasing doses of the methanolic leaves extract of P. pinnata on hematological parameters in rats. Materials and Methods: Thirty-six male Wistar albino rats were grouped into six groups of six animals each. Five doses; 50,100, 200, 400 and 800 mg/kg body weight of the P. pinnata extract were administered separately to five groups. The sixth group served as a control and received only the vehicle (70% physiological saline: 30% Tween 80 [v/v]). Administration was done orally daily for 28 days at 24 h interval. On day 29, the animals were made inactive, blood was then collected from the heart and various hematological parameters were evaluated. Statistical Analysis: Analysis of variance was employed. Results: The packed cell volume and red blood cell count increased significantly (P < 0.05) in the treatment groups except at 200 mg/kg dose. The hemoglobin concentration increased in all the treatment groups. The values for the neutrophils at 50, 100, 200 and 800 mg/kg doses were higher than that of the control. The white blood cell count increased significantly (P < 0.05) at 50 and 400 mg/kg doses compared to the control and exceeded the normal physiological range. Conclusion: The maximum tolerable dose is 200 mg/kg body weight of the methanolic leaves extract of P. pinnata and the extract has anti-anemic property with the ability to increase neutrophils count.


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