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ORIGINAL ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 5  |  Page : 15-19

Antioxidant and Antiacetylcholinesterase Activity of Teucrium hyrcanicum


1 Department of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran 14155 - 6451, Iran
2 Department of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran 14155 - 6451; Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
3 Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada
4 Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155 - 6451; Department of Traditional Pharmacy, Faculty of Traditional Medicine and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran 14155 - 6451, Iran
5 Department of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran 14155 - 6451, Iran; Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada

Correspondence Address:
Dr. Mahnaz Khanavi
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155 - 6451, Iran

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.157993

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Background: Teucrium hyrcanicum belonging to the Lamiaceae family is a native plant in Iran; it is called Maryam nokhodi-e-jangali in Farsi. Objective: The aim of this study is to evaluate acetylcholinesterase inhibition (AChEI), antioxidant activity and flavonoids content of T. hyrcanicum methanol extract. Materials and Methods: The air-dried and the ground aerial parts of T. hyrcanicum were extracted by percolation method with methanol. Antioxidant activity of the extract was investigated by using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power assay (FRAP) methods. In addition, AChEI and flavonoid content of T. hyrcanicum methanol extract were measured. Results: The results showed that total flavonoid content of T. hyrcanicum in reference to the standard curve for quercetin was 20.70 ± 0.05 mg quercetin equivalents/g of extract. In the FRAP method, the antioxidant activity of T. hyrcanicum extract and butyl hydroxyanisole (BHA) (as a positive control) were 657.5 ± 0.04 and 880 ± 0.06 mmol Fe II/1 g dried extract. According to results of DPPH assay, half maximal inhibitory concentration (IC 50 ) value for DPPH radical-scavenging activities of T. hyrcanicum methanol extract, vitamin E and BHA were 74.6, 14.12 and 7.8 μg/mL, respectively. IC 50 value for AChEI of T. hyrcanicum and donepezil as a positive control were 2.12 mg/mL and 0.013 mg/mL. Conclusion: The results of the present study showed T. hyrcanicum is a natural antioxidant that the flavonoid content can be responsible for extract effects.


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