Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 4  |  Page : 393-396

The evaluation of the activity of medicinal remedies of plant and animal origin on the regeneration of the earthworms' tail segments


Federal State Budgetary Educational Establishment of the Higher Professional Education, "Irkutsk State University", Scientific Research Institute of Biology, Russian Federation, Russia

Correspondence Address:
Viktor Alexandrovich Bybin
Irkutsk 664074 Russian Federation,4th Zheleznodorozhnaya Street, 100-122, Irkutsk region
Russia
Login to access the Email id

Source of Support: The work was carried out with the support of the Ministry of the Education of the Russian Federation in the frames of the realization of the project part of the state task in the field of scientific activity (Task 13.1263.2014 / K on 11/07/2014) and with the financial support of the grant of the Russian Foundation for Basic Research 14-04-31999, Conflict of Interest: None


DOI: 10.4103/0974-8490.159581

Rights and Permissions

Now, in the global community there is enough hard recommendation to replace the vertebrate test animals into simpler organisms at the development, testing, and evaluation of the quality pharmaceuticals. The feature of planarian to regenerate in new individual planarian from a piece, which is only 1/7 of the original animal, allowed to create the alternative methods of testing of drugs, dietary supplements, water quality, influence of electromagnetic fields, and other radiations. The tests on planarian can replace the ones that are held today on mammals. However, the lacks of the bioassays based on the planarian regeneration are the need for complex and expensive video equipment for recording the regrowth of worms' body, the difficulties of culturing of flatworms and fairly long period of response. These difficulties can be avoided by using another group of the worms of type Annelida. The new individual can be fully recovered only from the front half of the body in many species of earthworms. Thus, the influence of the pharmaceuticals from earthworms, mummy, and Orthilia secunda on the ability of earthworms to regenerate lost tail segments has been investigated. The relations of the activity of preparations tested with doses and the time of the storage have been revealed. The principal possibility of applicability of the test reaction studied as a way to evaluate the effects and quality of remedies based on medicinal plants and earthworms has been shown.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2054    
    Printed35    
    Emailed0    
    PDF Downloaded21    
    Comments [Add]    

Recommend this journal