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ORIGINAL ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 4  |  Page : 314-321

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens


1 Department of Marine Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 Department of Marine Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Ahmad Reza Gohari
Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran 1417614411
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.167893

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Background: Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods. Objective: In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations. Materials and Methods: For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods. Results: Six sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), β-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including 1 H-NMR, 13 C-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC 50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control. Conclusion: Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.


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