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Year : 2015  |  Volume : 7  |  Issue : 1  |  Page : 7-13

Minerals salt composition and secondary metabolites of Euphorbia hirta Linn., an antihyperglycemic plant


1 Faculty of Pharmaceutical and Biological Sciences, University of Félix HouphouŽt Boigny Cocody Abidjan, 22 BP 747 Abidjan 22, Côte d'Ivoire
2 Department of Traditional Medicine, Faculty of Pharmaceutical Sciences University of Bamako; Faculty of Pharmaceutical Sciences of Bamako, Bamako, Mali
3 Faculty of Biological Sciences, University of Péléforo Gon Coulibaly, BP 1328 Korhogo

Correspondence Address:
N'Guessan Bra Yvette Fofie
Faculty of Pharmaceutical and Biological Sciences, University of Félix HouphouŽt Boigny Cocody-Abidjan, 22 BP 747 Abidjan 22, Côte d'Ivoire

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.147131

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Phytochemical study and research on acute toxicity were performed on the aerial parts (leaves and stems) of Euphorbia hirta Linn. The phytochemical screening and chromatography revealed the presence of saponin, sterol, terpene, alkaloids, polyphenols, tannins and flavonoids and especially mucilage. The evaluation of total polyphenols and total flavonoids gave 120.97 ± 7.07 gallic acid equivalents (GAE) mg/g (mg of GAE/g of extract) of dry extract and 41.4 ± 0.5 mg quercetin equivalent per gram (QE/g) (mg of QE/g of plant extract) of dry extract respectively. The physicochemical study revealed moisture content of 7.73% ± 0.00%, total ash 7.48% ± 0.03%. Sulfuric ash 9.05% ± 0.01%, hydrochloric acid insoluble ash of 0.8% ± 0.02%. The search for minerals salt revealed the presence of Cr, Zn, K, Ca and Mg having an important role in glucose metabolism. The acute toxicity study showed that the toxic dose may be above 3000 mg/kg. The results of these studies indicate that extracts from the leaves and stem of E. hirta Linn. contains trace elements and minerals salt and bioactive secondary metabolites which explain their therapeutic uses for treating diabetes mellitus.


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