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ORIGINAL ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 1  |  Page : 121-125

Isolation, structural characterization and in silico drug-like properties prediction of a natural compound from the ethanolic extract of Cayratia trifolia (L.)


1 Department of Biochemistry, Karpagam University, Eachanari, Coimbatore, Tamil Nadu, India
2 Department of Bioinformatics, Karpagam University, Eachanari, Coimbatore, Tamil Nadu, India
3 Department of Chemistry, Karpagam University, Eachanari, Coimbatore, Tamil Nadu, India
4 Department of Biochemistry, Karpagam University, Eachanari, Coimbatore, Tamil Nadu; Department of Bioinformatics, Karpagam University, Eachanari, Coimbatore, Tamil Nadu, India

Correspondence Address:
Dr. Velliyur Kanniappan Gopalakrishnan
Departments of Biochemistry and Bioinformatics, Karpagam University, Coimbatore - 641 021, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.147226

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Background: Natural products have continually played an important role in drug discovery because it serves as active principles in drugs as well as templates for synthesis of new drugs. Cayratia trifolia (L.) is a medicinal plant, which has been reported to have antiviral, antibacterial, antiprotozoal, hypoglycemic, anticancer and diuretic activities. Objective: Therefore, the objective of this study is to isolate and identify the natural compound from the ethanolic extract of Cayratia trifolia (L.) and to predict the Absorption, Distribution, Metabolism and Excretion (ADME) properties of isolated natural compound. Materials and Methods: Column chromatography and thin layer chromatography were used to isolate the natural compound and Fourier-transform infrared (FTIR) spectroscopy was used to predict the functional groups present in the isolated natural compound. The structural characterization studies were functionally carried out using 1 H, 13 C, two-dimensional nuclear magnetic resonance (NMR) and mass spectrometry methods. Results: FTIR showed that, the groups of OH, C-H, C = C may be present in the isolated natural compound. 1 H, 13 C, two-dimensional NMR and mass spectrometry data suggests that the isolated natural compound probably like linoleic acid. In silico ADME properties, prediction of the compound was under acceptable range. Conclusion: Based on the results, it can be concluded that, the isolated natural compound of linoleic acid that has been exhibited good medicinal properties.


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