Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 306-311

A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration


1 Department of Basic Medical Sciences, The University of The West Indies Mona Campus, Kingston, Jamaica
2 Tropical Medicine Research Institute, The University of The West Indies Mona Campus, Kingston, Jamaica
3 Department of Haematology, The University of The West Indies Mona Campus, Kingston, Jamaica
4 Department of Physiology, University of Calabar, Calabar, Nigeria
5 Federal University of Technology, Owerri, Nigeria

Correspondence Address:
Chukwuemeka Nwokocha
Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Mona, Kingston 7
Jamaica
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.138278

Rights and Permissions

Context and Objectives: Lead (Pb) toxicity leads to cell damage in many organs of the body. Using different treatment interventions and modes of administration we comparatively examined the protective ability of some medicinal plants on liver Pb accumulation. Materials and Methods: Rats were fed on either 7% w/w Zingiber officinale, 7% w/w Allium sativum, 10% w/w Lycopersicon esculentum, 5%, w/w Garcinia kola (all in rat chow), while Pb (100 ppm) was given in drinking water. The additives were administered together with (mode 1), a week after exposure to (mode 2) or a week before metal exposure to (mode 3) the metal for a period of 6 weeks. The metal accumulations in the liver were determined using atomic absorption spectrometry and compared using analysis of variance. Results: Some additives significantly (P < 0.05) reduced, while others enhanced Pb accumulation. Mode 2 yielded the highest mean % protection and mode 3 the lowest, no significant interaction between modes of administration and time of measurement in their relationships to percentage protection, but there was statistically significant (P < 0.05) interaction between modes of administration and additive used in their relationships to percentage protection. Conclusion: Protective effects of medicinal plants are varied and depend on the nature of lead exposure.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1917    
    Printed44    
    Emailed0    
    PDF Downloaded18    
    Comments [Add]    

Recommend this journal