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ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 1  |  Page : 52-57

The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery


1 Department of Pharmacology, Midnapore Medical College, Paschim Medinipur, West Bengal, India
2 Department of Anaesthesiology, College of Medicine and Sagore Dutta Hospital, West Bengal, India
3 Department of Anaesthesiology, NRS Medical College, West Bengal, India
4 Department of Anaesthesiology, Bangur Institute of Neurology, West Bengal, India
5 Department of Anaesthesiology, I.P.G.M.E.R, Kolkata, West Bengal, India

Correspondence Address:
Anjan Das
174 Gorakshabashi Road, Royal Plaza Apartment, Nagerbazar, Kolkata - 28, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.122918

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Background: Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. Objective: The study was carried out to compare the efficacy of ginger (Zingiber officinale) added to Ondansetron in preventing PONV after ambulatory surgery. Materials and Methods: It was a prospective, double blinded, and randomized controlled study. From March 2008 to July 2010, 100 adult patients of either sex, aged 20-45, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A[(n = 50) receiving (IV) Ondansetron (4 mg) and two capsules of placebo] and Group B[(n = 50) receiving IV Ondansetron (4 mg) and two capsules of ginger] simultaneously one hour prior to induction of general anaesthesia (GA) in a double-blind manner. One ginger capsule contains 0.5 gm of ginger powder. Episodes of PONV were noted at 0.5h, 1h, 2h, 4h, 6h, 12h and 18h post- operatively. Statistical Analysis and Results: Statistically significant difference between groups A and B (P < 0.05), was found showing that ginger ondansetron combination was superior to plain Ondansetron as antiemetic regimen for both regarding frequency and severity. Conclusion: Prophylactic administration of ginger and ondansetron significantly reduced the incidence of postoperative nausea and vomiting compared to ondansetron alone in patients undergoing day care surgery under general anaesthesia.


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