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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 3  |  Page : 173-178

Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents


1 Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ibadan, Nigeria
2 Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ibadan, Nigeria
3 Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

Correspondence Address:
Samuel Adetunji Onasanwo
Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.112423

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Background: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. Materials and Methods: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. Results: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. Conclusion: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.


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