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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 3  |  Page : 169-172

Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis


1 Department of Pharmacy-Biology, University of Prishtina, Prishtina, Kosovo
2 Department of Biomedical Sciences, Centre for Biomedical Research, University of Dhaka, Bangladesh

Correspondence Address:
Muhammad Feroz Hayat Khan
Centre for Biomedical Research, University of Dhaka, Dhaka 1000
Bangladesh
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Source of Support: DGHS-011 and Erasmus Mundus mobility program,, Conflict of Interest: None


DOI: 10.4103/0974-8490.112422

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Background: Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough. Aim: In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration-response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nω-nitro-l-arginine methyl ester (L-NAME). Dose-response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM ( P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.


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