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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 2  |  Page : 109-112

The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes


1 Division of Pharmacognosy, Bengal School of Technology (A College of Pharmacy), Hooghly, India
2 Bengal Institute of Pharmaceutical Sciences, Nadia, India
3 Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

Correspondence Address:
Sanjib Bhattacharya
Pharmacognosy Division, Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hooghly, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.110540

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Background: Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes. Objective: The present study was aimed at the evaluation of in vitro antileishmanial effect of triterpenoid fraction from T. dioica root (CETD). Materials and Methods: The antileishmanial activity of CETD was evaluated against Leishmania donovani (strain MHOM/IN/83/AG83)) promastigotes by in vitro promastigote cell toxicity assay by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide). Potassium antimonyl tartrate was used as reference. Results: Here, CETD markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner and demonstrated IC 50 value of 18.75 μg/ml. The reference drug potassium antimonyl tartrate exhibited IC 50 of 7.52 μg/ml. Conclusion: From the present study it can be inferred that the triterpenoid fraction of T. dioica root exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.


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