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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 1  |  Page : 17-21

Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum


1 Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Egypt
2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Dokki, Cairo, Egypt
3 Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt

Correspondence Address:
Mahmoud I Nassar
Department of Chemistry of Natural Compounds, National Research Centre, 12622 Dokki,Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.105643

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Background: Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation. Materials and Methods: Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves. Results: Identification of a new flavone glycoside, acacetin 8-C-β-D- glucopyranosy l-(1→2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD 50 ) revealed that the different extracts were safe.


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