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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 1  |  Page : 10-16

Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies


1 Department of Pharmacology, University of Ghana Medical School, Ghana
2 Department of Medical Laboratory Sciences, School of Allied Health Sciences, Ghana
3 Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana
4 Animal Experimentation Unit, NMIMR, Ghana
5 Center for Scientific Research into Plant Medicine, Mampong, Akuapim, Ghana
6 Department of Clinical Pathology, NMIMR, Ghana

Correspondence Address:
George A Asare
Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle-bu, Accra
Ghana
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Source of Support: From the College of Health Sciences, University of Ghana, Legon, Ghana,, Conflict of Interest: None


DOI: 10.4103/0974-8490.105640

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Background : Croton membranaceus (CM) is used for benign prostate hyperplasia treatment. Objective : Sub-chronic toxicity studies are non-existent and provided the basis for this study. Materials and Methods : 90 days oral administration of a low dose (LD) (30 mg/kg b. wt.), medium dose (MD) (150 mg/kg b. wt.), and high dose (HD) (300 mg/kg b. wt.) CM aqueous root extract to 3 groups (n=6 each) of male Sprague-Dawley rats, alongside a control group, was undertaken. Urinalysis, hepato-renal function tests, lipid profile, cardiac enzymes, and routine hematology tests were performed. Results : Triglyceride levels (C=1.05±0.19, LD=0.64±0.08, MD=0.55±0.04, HD=0.50±0.02 mmol/L) were significantly reduced (P<0.05). Very low density lipoprotein (C=0.48±0.09, LD=0.29±0.04, MD=0.25±0.02, HD=0.23±0.01 mmol/L) decreased significantly (P<0.05). Cardiac enzymes-creatinine kinase (C=568±172, LD=315±79, MD=441±209, HD=286±81 IU/L) decreased markedly (P<0.05) alongside lactate dehydrogenase (C=2675±875, LD=1667±1229, MD=1186±442, HD=855±239 IU/L) (P<0.05). Conclusion : C. membranaceus aqueous root extract is non-toxic but demonstrates anti-atherogenic and anti-ischemic potentials.


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