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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 4  |  Page : 225-229

In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana: Adenia cissampeloides (Planch.) Harms., Termina liaivorensis A. Chev, and Elaeis guineensis Jacq


1 Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, Kumasi, Ghana
2 Department of Immunology, Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
3 Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, Kumasi, Ghana

Correspondence Address:
Kofi Annan
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi
Ghana
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.102270

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Background: Herbal remedies of Adenia cissampeloides, Terminalia ivorensis, and Elaeis guineensis among others have been used in Ghana for the treatment of various ailments including malaria. However, most of these remedies have not been scientifically investigated. Objective: This study, therefore, seeks to investigate the anti-plasmodial activity of these plants. Materials and Methods: The ethanolic extracts of A. cissampeloides stem, T. ivorensis stem bark, and E. guineensis leaves were tested for in vitro anti-plasmodial activity against chloroquine-resistant strains of Plasmodium falciparum. Thin blood films were used to assess the level of parasitemia and growth inhibition of the extracts. Results: The IC 50 of A. cissampeloides, T. ivorensis, and E. guineensis were 8.521, 6.949, and 1.195 μg/ml, respectively, compared to artesunate with IC 50 of 0.031 μg/ml. Conclusion: The result of this study appears to confirm the folkloric anti-malarial use these plants.


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