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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 3  |  Page : 161-165

Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves


1 Department of Biological Chemistry, Molecular Bioprospection Post-graduation Program, Laboratory of Natural Products Research, Regional University of Cariri, Crato, CE, Brazil
2 Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Fortaleza, CE, Brazil

Correspondence Address:
Jose Galberto M Costa
Department of Biological Chemistry, Regional University of Cariri, Rua Cel. Antônio Luiz 1161, Pimenta - 63105-000, Crato-CE
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.99080

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Background: Cordia verbenacea is a Brazilian coastal shrub popularly known as "erva baleeira". The essential oil from fresh leaves was obtained by hydrodistillation and analyzed by CG/MS. The main components were identified as β-caryophyllene (25.4%), bicyclogermacrene (11.3%), δ-cadinene (9.%) and α-pinene (9.5%). In this study, the antimicrobial activity of Cordia verbenacea was evaluated. Materials and Methods: The minimal inhibitory concentration (MIC) of the essential oil was obtained using the broth microdilution assay (from 512 to 8 μg/ml). Results: The results showed that the essential oil presented fungistatic activity against Candida albicans and Candida krusei and antibacterial activity against Gram-positive strains (Staphylococcus aureus and Bacillus cereus) and against multiresistant Gram-negative (Escherichia coli 27), in all tests the MIC was 64 μg/ml. When the essential oil was associated to aminoglycosides (subinhibitory concentrations, MIC/8), a synergic and antagonic activity was verified. The synergic effect was observed to the amikacin association (MIC reduction from 256 mlto 64 μg/ml) in all strains tested. Conclusion: The essential oil of Cordia verbenacea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.


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