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ORIGINAL ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 3  |  Page : 214-219

Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats


1 Department of Pharmacology, Sudhakarrao Naik Institute of Pharmacy, Pusad, Yavatmal, Maharashtra, India
2 Department of Pharmacology, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, Gujarat, India

Correspondence Address:
Shruti S Shiromwar
Department of Pharmacology, Sudhakarrao Naik Institute of Pharmacy, Nagpur Road, Pusad - 445 204, Dist. Yavatmal, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.85012

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Background: Doxorubicin (DOX) is the most active cytotoxic agents having efficacy in malignancies either alone or combined with other cytocidal agents. The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity. Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug. This study is based on the possible protective effects of combination of p-coumaric acid (PC) and naringenin (NR) on DOX induced cardiac toxicity in male Swiss albino rats. Methods: Total nine groups of Swiss albino rats were used, Group I (vehicle control) receive saline solution daily and Group II (disease control) receive saline solution daily up to 29 th day and at 30 th day a single dose of DOX (15 mg/kg i.p.) is given. PC alone (100 mg/kg/day p.o.) and (200 mg/kg/day p.o.) also NR alone (15 mg/kg/day) orally administer for 30 days. Similarly a standard drug Vit. E (100 mg/kg/day) administers alone for 30 days. Group PC/DOX and PC and NR/DOX receive PC (200 mg/kg/day) and combine PC (200 mg/kg/day).Results: Doxorubicin induced marked biochemical alterations characteristic of cardiac toxicity including increase in MDA level and decrease SOD, CAT & GSH level but prior administration of combination of PC & NR ahead of doxorubicin challenge ameliorated all these biochemical markers. Conclusion: The study proves the beneficial effects of combination of PC and NR in protecting animal against DOX induced cardiotoxicity.


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