Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 


 
 Table of Contents 
LETTER TO THE EDITOR
Year : 2011  |  Volume : 3  |  Issue : 2  |  Page : 147  

Are we in the polyphenols era?


Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hooghly 712102, West Bengal, India

Date of Web Publication8-Jun-2011

Correspondence Address:
Sanjib Bhattacharya
Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hooghly-712 102, West Bengal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.81966

Rights and Permissions

How to cite this article:
Bhattacharya S. Are we in the polyphenols era?. Phcog Res 2011;3:147

How to cite this URL:
Bhattacharya S. Are we in the polyphenols era?. Phcog Res [serial online] 2011 [cited 2020 May 31];3:147. Available from: http://www.phcogres.com/text.asp?2011/3/2/147/81966

Sir,

Polyphenols constitute a group comprising about 8000 different molecules, among which flavonoids are the most studied family. Polyphenols are potent antioxidants abundant in medicinal plants, fruits, vegetables and particularly in derived food products such as chocolate, tea and wine. This more 'natural' approach to antioxidant supplementation seems to be promising, since the antioxidant capacity of these compounds is not simply related to direct scavenging of reactive oxidant species (ROS), but also to inhibition of enzymatic sources of oxidative stress and augmentation of endogenous non-enzymatic and enzymatic antioxidant systems. Benefits from polyphenol-rich medicinal plants, foods and beverages are likely to arise from multiple pathways, and the antioxidant property appears to be only one of these. [1],[2]

Despite these promising data, further questions remain to be solved. First of all, it remains unclear how potent are the antioxidant properties of polyphenols and which molecules in this class are the most potent ones in vivo. Further, it needs to be clarified whether these compounds possess other properties beyond their chemical antioxidant ones in specific pathophysiological conditions. As well, the amount of active constituents present in medicinal plants, food and beverages show remarkable variability due to genetic and agronomic factors, post-harvest handling, and subsequent processing or formulation steps. Such problems could apparently be overcome by using standardized formulations for supplementation, but except a few cases (like silymarin, green tea etc) this field still awaits exploration for the majority of the products. Unfortunately, the human studies on polyphenolics done to date are of such variable design, quality and results that no definitive conclusions about degrees of effectiveness in the treatment or prevention of diseases can yet be made. Better quality multifaceted clinical trials are therefore necessary. At this moment, strong evidence obtained with long-term randomized controlled clinical trials is still lacking, and no conclusion on the efficacy and safety of flavonoid supplementation in pathophysiological conditions can be reached. [3],[4]

Nevertheless, polyphenols are more promising than other direct synthetic antioxidants, whose clinical efficacy is limited by the disadvantageous biochemical alterations. [5] Thus, rather than considering the conventional antioxidant hypothesis for polyphenols, we need more hypothesis-driven and rigorous clinical trial designs, guided by a deeper understanding of the complex physiology of ROS including other possible interrelated and independent mechanisms.

Therefore, the future research should more clearly address the differences between different kinds of polyphenols, in order to identify which type of intervention would constitute the most feasible and effective approach for prophylactic and therapeutic purposes. Additionally, definitive research should aim to clarify whether these encouraging results can be translated into reduction or amelioration of disease conditions.

 
   References Top

1.Stoclet JC, Schini-Kerth V. Dietary flavonoids and human health. Ann Pharm Fr 2011;69:78-90.  Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Saraf S, Ashawat MS, Saraf S. Flavonoids: A nutritional protection against oxidative and UV induced cellular damages. Phcog Rev 2007;1:30-40.  Back to cited text no. 2
  Medknow Journal  
3.Miller AL. Antioxidant flavonoids: Structure, function and clinical usage. Alt Med Rev 1996;1:103-11.  Back to cited text no. 3
    
4.Kay CD. The future of flavonoid research. Br J Nutr 2010;104:S91-5.  Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.Harnafi H, Amrani S. Flavonoids as potent phytochemicals in cardiovascular diseases prevention. Phcog Rev 2007;1:193-202.  Back to cited text no. 5
  Medknow Journal  



This article has been cited by
1 Arsenic Induced Myocardial Toxicity in Rats: Alleviative Effect ofTrichosanthes dioicaFruit
Sanjib Bhattacharya,Sanjit Kumar Das,Pallab Kanti Haldar
Journal of Dietary Supplements. 2014; 11(3): 248
[Pubmed] | [DOI]
2 Comparative study of allelopathic effects of green tea and black tea
Chatterjee, P. and Chandra, S. and Dey, P. and Bhattacharya, S.
Current Trends in Biotechnology and Pharmacy. 2013; 7(2): 644-649
[Pubmed]
3 Comparative in vitro antibacterial evaluation of different extracts of Camellia sinensis leaves form different geographical locations in India
Chauhan, D.S. and Bhattacharya, S. and Mueen Ahmed, K.K.
Pharmacognosy Journal. 2013; 5(2): 87-90
[Pubmed]
4 Antioxidant and anti-inflammatory properties Hymenodictyon excelsum bark
Biswakanth Kar,Abimanyu Nepal,R. B. Suresh Kumar,Narayan Dolai,Sanijb Bhattacharya,Upal K. Mazumder,Pallab K. Haldar
Oriental Pharmacy and Experimental Medicine. 2013; 13(2): 103
[Pubmed] | [DOI]
5 Comparative in vitro antibacterial evaluation of different extracts of Camellia sinensis leaves form different geographical locations in India
Devendra Singh Chauhan,Sanjib Bhattacharya,K.K. Mueen Ahmed
Pharmacognosy Journal. 2013; 5(2): 87
[Pubmed] | [DOI]
6 Anti-nociceptive activity of Mikania scandens flower in albino mice: involvement of CNS depressant role
Sanjib Bhattacharya,Sangita Chandra,Protapaditya Dey
Oriental Pharmacy and Experimental Medicine. 2013; 13(3): 199
[Pubmed] | [DOI]
7 trichosanthes dioica fruit extract ameliorates arsenic-induced brain toxicity in male albino rats
bhattacharya, s. and haldar, p.k.
journal of environmental pathology, toxicology and oncology. 2013; 32(2): 141-148
[Pubmed]
8 Trichosanthes dioica Fruit Ameliorates Experimentally Induced Arsenic Toxicity in Male Albino Rats Through the Alleviation of Oxidative Stress
Sanjib Bhattacharya,Pallab Kanti Haldar
Biological Trace Element Research. 2012; 148(2): 232
[Pubmed] | [DOI]
9 Comparative in vitro antioxidant evaluation of different extracts of Camellia sinensis leaves form different geographical locations in India
Devendra Singh Chauhan,Sanjib Bhattacharya,K.K. Mueen Ahmed
Pharmacognosy Journal. 2012; 4(33): 46
[Pubmed] | [DOI]
10 Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein
Sangita Chandra,Priyanka Chatterjee,Protapaditya Dey,Sanjib Bhattacharya
Asian Pacific Journal of Tropical Biomedicine. 2012; 2(1): S178
[Pubmed] | [DOI]
11 Comparative in vitro antioxidant evaluation of different extracts of Camellia sinensis leaves from different geographical locations
Devendra Singh Chauhan,Sanjib Bhattacharya,Bandar AlDhubaib,KK Mueen Ahmed
Pharmacognosy Journal. 2012; 4(31): 44
[Pubmed] | [DOI]
12 Neuropharmacological activities of Mikania scandens root
Dey, P. and Chandra, S. and Bhattacharya, S.
Global Journal of Pharmacology. 2012; 6(3): 193-198
[Pubmed]
13 Assessment of allelopathic property of Mikania scandens root
Dey, P. and Chandra, S. and Chatterjee, P. and Bhattacharya, S.
Current Trends in Biotechnology and Pharmacy. 2012; 6(3): 322-327
[Pubmed]
14 Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in vitro study
Chatterjee, P. and Chandra, S. and Dey, P. and Bhattacharya, S.
Journal of Advanced Pharmaceutical Technology and Research. 2012; 3(2): 136-138
[Pubmed]
15 Neuropharmacological properties of Mikania scandens (L.) Willd. (Asteraceae)
Dey, P., Chandra, S., Chatterjee, P., Bhattacharya, S.
# # Journal of Advanced Pharmaceutical Technology and Research. 2011; 2(4): 255-259
[Pubmed]



 

Top
  
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References

 Article Access Statistics
    Viewed1873    
    Printed91    
    Emailed0    
    PDF Downloaded26    
    Comments [Add]    
    Cited by others 15    

Recommend this journal