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ORIGINAL ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 1  |  Page : 2-8

Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals


1 Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria;Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
2 Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
3 Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria

Correspondence Address:
A A Oyagbemi
Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria

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Source of Support: The fi nancial supports from the Academy of Sciences for the Developing World (TWAS) and the Council of Scientifi c & Industrial Research (CSIR) for the Post-Doctoral Fellowship given to the Dr. Adetunji Onasanwo are appreciated. The research facilities provided by the CDRI, Lucknow, India, Conflict of Interest: None


DOI: 10.4103/0974-8490.79108

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Background: The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB) whole fruit in laboratory rats. Methods: The anti-ulcer property of the ethanolic extract of the whole fruit of Lagenaria breviflora (LB) was assessed using the cold-restraint stress-induced (CRU) gastric ulcer, pyloric ligation-induced (PL) gastric ulcer, aspirin-induced (ASP) gastric ulcer and alcohol-induced (AL) gastric ulcer models. The scavenging activity of the LB extract was examined with 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), Nitric oxide, Hydroxyl radical and Superoxide anion scavenging models. Results: EELB (50, 100, 150 and 200 mg/kg, b.w.) protected against the CRU gastric ulcer dose dependently. Similarly, 150 mg/kg b.w. of the LB extract protected against the PL gastric ulcer, ASP gastric ulcer and AL gastric ulcer and was comparable to omeprazole (10 mg/kg b.w.) or Suscralfate (500 mg/kg b.w.), respectively. The in vitro antioxidant activity of LB was demonstrated by its ability to quench free radicals generated by nitric oxide and superoxide anion with a concomitant scavenging potential against DPPH-induced radical formation. Conclusion: Taken together, the study showed that the whole fruit extract possess potent anti-ulcer and antioxidant activities.


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