Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 6  |  Page : 364-367

Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves


1 Department of Pharmacognosy, L.L.R. College of Pharmacy, Moga, Punjab-142001, India
2 Department of Pharmacognosy, Adesh College of Pharmacy, Bathinda - 151001, Punjab, India
3 Department of Pharmacognosy, I.S.F. College of Pharmacy, Moga - 142 001, Punjab, India

Correspondence Address:
Manjit Singh
Department of Pharmacognosy, L.L.R. College of Pharmacy, Moga - 142 001, Punjab
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.75456

Rights and Permissions

Background: The objective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL) (Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin. Methods: Aqueous extract of the leaves was prepared by cold maceration. Results: The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P < 0.05) inhibition of paw oedema, 37.5% and 54.0% on 4 th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9% and 43.0% on 4 th day at the doses of 200 and 400 mg/kg, respectively. Conclusion: The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3306    
    Printed197    
    Emailed4    
    PDF Downloaded17    
    Comments [Add]    
    Cited by others 10    

Recommend this journal