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ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 6  |  Page : 359-363

Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats


1 Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121, India
2 A.R.College of Pharmacy, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120, India
3 Nutan Education Trust's B. Pharmacy College, At. Rampura, Po. Kakanpur, Tal. Godhra, Dist. Panchmahal, Gujarat - 389 713, India

Correspondence Address:
S H Shukla
Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.75455

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Aim: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated. Materials and Methods: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre. Results: Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count. Conclusion: This drug is found to be a potential immunostimulant.


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