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ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 1  |  Page : 26-30

Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats


Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India

Correspondence Address:
Nirmal K Bairwa
Herbal Drug Technology Laboratory, G. H. Patel Pharmacy Building, Donor's Plaza, Fatehgunj, Vadodara, Gujarat - 390 002
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8490.60584

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The present study reports protective activity of ethyl acetate fraction of methanol extract of stem bark of Ceiba pentandra against paracetamol-induced liver damage in rats. The ethyl acetate fraction (400 mg/kg) was administered orally to the rats with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (100 mg/kg) was used as positive control. High performance thin layer chromatography (HPTLC) fingerprinting of ethyl acetate fraction revealed presence of its major chemical constituents. A significant (P < 0.05) reduction in serum enzymes GOT (ALT), aspartate aminotransferase (AST), GPT alkaline phosphatase (ALP), total bilirubin content and histopathological screening in the rats treated gave indication that ethyl acetate fraction of methanolic extract of Ceiba pentandra possesses hepatoprotective potential against paracetamol-induced hepatotoxicity in rats.


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