Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
RESEARCH ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 6  |  Page : 387-391

Antifungal activity of Tabernaemontana stapfiana Britten (Apocynaceae) organic extracts


1 Kenya National Public Health Laboratory Services, P.O. Box 20176, 00100 GPO, Nairobi, Kenya
2 Center for Microbiology, Research Kenya Medical Research Institute, P.O. Box 2632, 00202, Nairobi, Kenya
3 Department of Physical Science, Masinde Muliro University of Science and Technology, P.O. Box 190, 50100 Kakamega, Kenya
4 Chemistry Department, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi, Kenya
5 Department of Pharmacy and Complementary Medicine, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi, Kenya
6 Department of Plant and Microbial Sciences, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi, Kenya

Correspondence Address:
P Okemo
Department of Plant and Microbial Sciences, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi
Kenya
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The methanol and successive (hexane, dichlroromethane, ethyl acetate and methanol) extracts of leaves, fruits, root and stem barks of Tabernaemontana stapfiana Britten were investigated for antifungal activity against four fungi; Candida albicans, Cryptococcus neoformans, Microsporum gypseum and Trichophyton mentagrophytes. The extracts of the different plant parts showed varied activities against the tested fungi with the stem and root barks showing significant antifungal activities. The minimum inhibitory concentrations (MICs) of methanol and sequential extracts ranged between 31.25 and 8000 μg/ml while the minimum fungicidal concentrations (MFCs) ranged between 125 and 8000 μg/ml. Among the test microorganisms, Candida albicans was the most susceptible with the lowest MIC of 31.25 μg/ml followed by Cryptococcus neoformans with an MIC of 62.25 μg/ml. These results show that it is possible to find antifungal compounds in the extracts of T. stapfiana.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2121    
    Printed145    
    Emailed0    
    PDF Downloaded105    
    Comments [Add]    

Recommend this journal